About CERAMENT® G

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How Does it Work?

CERAMENT® G is the only antibiotic-eluting bone graft substitute that can remodel into bone4 and provide reliable, consistent, clinically relevant and safe local antibiotic elution5 to promote and protect bone healing.

CERAMENT® G comes in an all-in-one kit with a standardized mixing protocol to make bone void filling reproducible and predictable.

An FDA-Designated Breakthrough Device

Therapies that treat serious conditions and have demonstrated substantial improvement or is the first of its kind.

CERAMENT® G
DUAL MODE OF ACTION

PROMOTE BONE REMODELING

• Proven bone remodeling4
decor about debridement and injection
Debridement and Injection of CERAMENT® G

CERAMENT® is highly flowable to completely fill voids and cracks.

decor about bone is healed
Bone remodeling within 12 months:

The calcium sulfate in CERAMENT® is fully resorbed, hydroxyapatite is embedded in bone and natural bone building continues increasing mechanical strength.4

PROTECT BONE HEALING

• Safe and reproducible local antibiotic elution5
Graph: In vitro elution of gentamicin from CERAMENT G
* The minimum inhibitory concentration (MIC) is the lowest concentration
of a chemical, usually a drug, which prevents visible growth of bacterium.8
  1. Ferguson et al. ‘Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis’.
    J. Bone Joint Infect. 2019; 4(2): 76-84.
  2. Stravinskas et al. ‘Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute – In vitro and clinical release studies’.
    Bone Joint Res. 2016; 5:427–435
  3. S032/2020. BONESUPPORT data on file
  4. Aureus MBIC level: Mottola et al. ‘Susceptibility patterns of Staphylococcus aureus biofilms in diabetic foot infections’.
    BMC Microbiology 2016; 16:119. https:// core.ac.uk/download/pdf/71740102.pdf
  5. https://en.wikipedia.org/wiki/Minimum_inhibitory_concentration [accessed 24th September 2019].

Explore the Studies

View the Research Data

CERAMENT® G’s Antibiotic Elution

Graph: Sustained In-Vitro Elution
High burst of gentamicin above > 2000mg/L.
Stays well above MIC for 28 days.1

Sustained Elution

CERAMENT® G provides a high initial burst of gentamicin, with sustained elution above MIC (minimum inhibitory concentration) for 28 days.1

Graph: Detectable Gentamicin Levels in Urine
Complete elution at 30 days, helping to
reduce antibiotic resistant bacteria.2

Complete Elution

The gentamicin in CERAMENT® G is completely eluted at 30 days, helping to reduce the risk of inducing antibiotic resistant bacteria.2

Graph: Gentamicin Levels in Blood Serum
<3mg/L, well below the systemic
toxicity threshold of 10mg/L.2

Safe Elution

Blood serum elution of CERAMENT® G stays well below the systemic toxicity threshold.2

  1. Stravinskas et al. ‘Pharmacokinetics of gentamicin eluted from a regenerating bone graft substitute – In vitro and clinical release studies’. Bone Joint Res. 2016; 5:427–435.
  2. Stravinskas et al. ‘Antibiotic Containing Bone Substitute in Major Hip Surgery: A Long Term Gentamicin Elution Study’. J Bone Joint Infect. 2018; 3(2):68-72.
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