The Impact of Bone Infection
Bone infection can arise from fractures, orthopedic implants, diabetic foot ulcers, and hematogenous infection. It’s a devastating disease that can be irreversibly debilitating and can lead to limb amputation which significantly increases risk of mortality.1
Typical treatment involves multiple surgical interventions, using off-label and unproven mixing of products where patients experience a long and burdensome treatment journey. The healthcare burden to patients, providers and payers is significant.
CONSIDER THE IMPACT OF BONE INFECTION
CHRONIC OSTEOMYELITIS
~2 per 10,000
People diagnosed annually
with osteomyelitis in the US1
20-30%
Long term recurrence rate2,3
Underlying osteomyelitis due to trauma may present itself post-surgery. While the infected bone is removed through surgery, the infection often recurs.
FRACTURE-RELATED INFECTIONS
Up to 30%
Infection rate after open fractures 4
3-5%
Amputation rate to treat FRI 5
Infection can quickly establish itself after a fracture. For Gustilo-Anderson type Ill open tibial fractures, the estimated rate of infection is 12.3% for IIIB and 16.1% for IIIC.9
DIABETIC FOOT OSTEOMYELITIS
20%
Diabetic patients with infected
foot ulcers have underlying osteomyelitis6
15%
Patients will require amputation7
1 of 5
Patients will be readmitted within
30 days of lower extremity amputation8
Diabetic foot ulcers are the consequence of neuropathy and vascular disease. They are worsened by infection which, if it reaches the bone, may require surgical resection or amputation.