Antibiotic Elution
Pharmacokinetics of Gentamicin Eluted from a Regenerating Bone Graft Substitute - In Vitro and Clinical Release Studies
Authors: Stravinskas et al.
Publication: Bone & Joint Research (2016)
Summary: This study compares the elution of gentamicin from CERAMENT® G in vitro with elution and efficacy in clinical applications. The results showed that the elution pattern in vitro was comparable to that seen in patient studies.
Results:
- Elution for up to 28 days
- Antibiotic elution is not surface dependent
- High initial burst of gentamicin above 2000 mg/L
- Low serum concentrations well below toxic threshold of 10mg/L
Antibiotic Containing Bone Substitute in Major Hip Surgery: A Long Term Gentamicin Elution Study
Authors: Stravinskas et al.
Publication: Bone & Joint Research (2018)
Summary: Examines the antibiotic elution of CERAMENT® G in patients over a 30-day follow-up period. Also compares the pharmacokinetics of CERAMENT® G with gentamicin containing PMMA bone cement used in primary total hip arthroplasty.
Results:
- All of CERAMENT’S antibiotic is released
- Antibiotic elution is not surface dependent
- CERAMENT® has higher initial elution than PMMA
- Low serum concentrations well below toxic threshold of 10mg/L
Explore the Studies
CERAMENT® G’s Antibiotic Elution
Stays well above MIC for 28 days.1
Sustained Elution
CERAMENT® G provides a high initial burst of gentamicin, with sustained elution above MIC (minimum inhibitory concentration) for 28 days.1
reduce antibiotic resistant bacteria.2
Complete Elution
The gentamicin in CERAMENT® G is completely eluted at 30 days, helping to reduce the risk of inducing antibiotic resistant bacteria.2
toxicity threshold of 10mg/L.2
Safe Elution
Blood serum elution of CERAMENT® G stays well below the systemic toxicity threshold.2