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Bone Remodeling

Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis

Authors: Ferguson et al.
Publication: The Journal of Bone and Joint Infection (2019)
Summary: Patients with chronic osteomyelitis, treated by surgery, implantation of CERAMENT® G, and systemic antibiotics. 138 of these patients had minimum one-year radiographic follow-up (mean 1.7 yrs). 9 patients had subsequent surgery that allowed for histology of biopsies between 19 days-2 years after implantation of CERAMENT® G. Histology “confirmed active remodeling of [CERAMENT® G] into osteoid and lamellar bone”.
Results:
  • 163 patients
  • 2.5% fracture rate
  • 73.8% mean void filling
  • 95.7% infection eradication
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Autologous Iliac Bone Graft Compared with Biphasic Hydroxyapatite and Calcium Sulfate Cement for the Treatment of Bone Defects in Tibial Plateau Fractures - A Prospective, Randomized, Open-label, Multicenter Study*

Authors: Hofmann et al.
Publication: The Journal of Bone And Joint Surgery (American – 2020)
Summary: This non-inferiority study compared CERAMENT® BONE VOID FILLER to autograft in acute traumatic fractures of the proximal tibia. The study also compared bone remodeling and patient-reported outcome measures between the two treatment groups. *This study featured CERAMENT® BONE VOID FILLER.
Results:
  • Proven bone remodeling
  • CERAMENT® is as good as autograft
  • Less blood loss compared to autograft
  • Less post-op pain compared to autograft
  • Trend towards shorter duration of surgery
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Evidence-based Bone Healing

Bone Remodeling: Ex-Rays of Pre and Post-Operative Bone Healing
Bone remodeling before and after operation using CERAMENT® BVF autologous iliac bone graft.

CERAMENT® Autologous Iliac Bone Graft and Healing over 6 months

  • Level 1 randomized controlled trial (RCT) – the CERTIFY study involves 135 patients and shows that CERAMENT® BONE VOID FILLER (BVF) is as good as autograft (AIBG) in bone remodeling1*
  • One and only orthobiologic product with robust long-term evidence: 94% infection-free after 6 year follow-up2
  1. Hofmann A, Gorbulev S, Guehring T, Schulz AP, Schupfner R, Raschke M, Huber-Wagner S, Rommens PM; CERTiFy Study Group.
    Autologous Iliac Bone Graft Compared with Biphasic Hydroxyapatite and Calcium Sulfate Cement for the Treatment of Bone Defects in Tibial Plateau Fractures: A Prospective, Randomized, Open-Label, Multicenter Study.
    J Bone Joint Surg Am. 2020 Feb 5;102(3):179-193. doi: 10.2106/JBJS.19.00680. PMID: 31809394; PMCID: PMC7508276.
  2. McNally MA, Ferguson JY, Scarborough M, Ramsden A, Stubbs DA, Atkins BL.
    Mid- to long-term results of single-stage surgery for patients with chronic osteomyelitis using a bioabsorbable gentamicin-loaded ceramic carrier.
    Bone Joint J. 2022 Sep;104-B(9):1095-1100. doi: 10.1302/0301-620X.104B9.BJJ-2022-0396.R1. PMID: 36047024; PMCID: PMC9948464.

Bone Remodeling Videos

CERAMENT® The Bone Healing Journey

Video Cover Image: The Bone Healing Journey

The 5 Stages of Bone Remodeling

cover 12 months of CERAMENT Bone Remodeling
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